The Leaders Advancing

Biomanufacturing

We invest in companies driving the bioeconomy forward.

Smiles expected, not guaranteed.

The Most important problem Humans face in 2025

Our Portfolio Is Tackling

Trillion Dollar Problems

Here is what we look for in our portfolio companies:

Proven Science - Patented, rigorously vetted technology with clear IP ownership

Early Commercial Momentum - Secured pilot customers or licensing deals, and a pathway to $100 M+ in annual revenue.

Large Market, Cost Parity - Solutions that can meet or beat incumbent pricing in multi-billion-dollar sectors.

Exceptional Founders - Teams blending deep science with execution strength and the drive to grow fast.

Capital Advantage - Access to federal grants and non-dilutive programs that extend runway.

Billion-Dollar Upside - Minimum 20× return potential and a clear route to $1 B+ valuation at exit.

This is our formula for predictable success that drives value to our portfolio companies and investors.

We invest from seed to Series A, and like to finance engineering risk. We do not want to finance market risks, technical risks, etc. When we finance engineering risk, we have a high chance of success. This is the model First Bight is scaling with from Fund 1 to Fund 2.

Check out what each of our portfolio companies are up to!

The algenesis team is...

Scaling Bio-Based Polyurethane

77% of humans have microplastics in their blood.This is one of the largest problems we face in the 21st century.

Algenesis has developed a microplastic free and compostable material that can be used across industries. This material is called Soleic.

Algenesis was founded by Professor Stephen Mayfield, a leader from UC San Diego with 3 exits under his built.

Here are some use cases for Algenesis's material:

Barrier Layers For Single Use Packaging

Apparel & Shoes

Phone Cases

Foam Cushions (For Automotive and Furniture)

Durable Goods

The persephone team is...

Scaling Novel Probiotics

The silent war happening across the world is happening in the gut biome of every human.

The solution to this problem is scalable, low cost, novel probiotics that seed good bacteria in our gut biomes.

Here are some of the problems that the Persephone team is tackling as they revolutionize human health.

Disease Progression

Therapeutic Response

Nutrition

Longevity

The Visolis team is...

Scaling Carbon Negative Chemicals

In a world of petrochemicals, reliable supply chains of carbon negative materials is only increasing in demand.

The Visolis team has developed a technology that allows for scalable production of carbon negative platform molecules like isoprene (the precursor for rubber).

The Visolis team converts waste biomass and CO2 into everyday chemicals.

Here are some of the use cases the Visolis team is focused on:

Isoprene (Rubber)

Skin Creams / Personal Care

Fuels

Solvents

The via biofuels team is...

Scaling Sustainable Fuels and Chemicals

Platform molecules have become all the rage as the world seeks sustainable solutions in the chemical sector.

VIA is scaling their continuous fermentation technology and proprietary yeast production to disrupt multiple industries.

Here are some of the problems the VIA team is tackling:

Fuels

Personal Care

Textiles

Plastics

The r2dio team is...

Scaling Biomanufacturing Software

Process intelligence platforms are the unlock codes for large producers to predictably innovate.

R2DIO pulls all your process data, files, and tools into one searchable, context-rich platform.

Here are some of the impacts R2DIO's customers are experiencing as they use their technology:

50% Faster Process Development Cycles

Finding Millions Per Year in Extra Production Output

Cut Hours of Data Wrangling to Seconds

Plug Into Your Preexisting Data Tools

No Code - No IT Backlog - Connect, Search, & Decide

The Capra Biosciences team is...

Scaling Food Waste to Chemicals

There are certain chemicals that are extremely difficult to make through biomanufacturing.

Capra’s small, modular, plug-and-play reactors use thin layers of microbes (biofilms) to turn waste carbon into chemicals.

Capra's process makes high value chemicals faster and cheaper than standard fermentation while using very little water or energy.

Here are a few use cases they are focused on:

Cosmetics (like Retinol)

Adhesives

Pigments

Detergents

Lubricants

The industrial microbes team is...

Scaling Bio-Based Acrylic Acid

iMicrobes rewires naturally gas-eating bacteria to turn CO₂, methane, and even raw biogas into drop-in ingredients.

Waste gases go in, and premium climate-positive products come out the other side.

Plug their chassis into an electrolyzer or landfill flare and you can crank out all different types of chemistries, including:

Paints

Coatings

Biodegradable Plastics

Specialty Aroma Molecules

Beyond Capital

We Partner With Startups To Scale Impact

If you are looking for silent capital, you are in the wrong place.

We Lead Rounds

We write first checks for

seed through series A.

We Want Board Seats

We are actively involved in

strategy and governance.

We Make Introductions

We leverage our relationships to drive meaningful partnerships.

We Drive Efficiencies

We help our portfolio companies proficiently scale operations.

We Mitigate Risks

We identify and reduce scale up risks to increase shareholder value.

We Love Science

We nerd out on technology and

how it drives impact.

TESTIMONIALS

What Our Portfolio Companies Have to Say

We have created the leading biomanufacturing venture ecosystem.

“Partners who roll up their sleeves.”

"First Bight helped us source new feedstocks, connect with partners, unlock non-dilutive funding, & refine our go to market strategy."

- Steven Mayfield, CEO @ Algenesis

“Connecting the dots across industry.”

“Veronica & the First Bight team understand how we fit into the ecosystem & make valuable introductions to key industry partners.”

- Noah Helman, CEO @ iMicrobes

"First Bight has the vision and tools to build the bioeconomy."

"First Bight has built an incredible ecosystem to help scale the next generation of biomanufacturing companies."

- Liz Onderko, CEO @ Capra Biosciences

Smiles expected, not guaranteed.

And Sometimes, we like to have fun

The Secret Sauce of Biomanufacturing

Smiles expected, not guaranteed.

How To Bio?

Scaling Sustainable Chemistry

We have tailored our approach to support scale up challenges in biomanufacturing.

This laser focus helps startups, investors, corporates, and communities reap the rewards of First Bight's ecosystem.

If you are interested in investing in or scaling sustainable chemicals, please find a time to connect with our team.

Press from port co's

News From Our Portfolio

Stay up to date on advancements from First Bight's portfolio companies.

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